Body mass predicts the survival of patients with new international federation of gynecology and obstetrics stage IB1 and IB2 cervical carcinoma treated with radical hysterectomy

Introduction. Since 1897, when the first radical hysterectomy with lymphadenectomy was done by Wertheim in Vienna, this operation has had the central role in the surgical treatment of invasive cervical tumors. Material and methods. In the period from 1997 to 2010, 177 patients diagnosed with invasive cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) stage IB1 - II were operated at the Department of Obstetrics and Gynecology in Banja Luka. All patients underwent radical hysterectomy by Wertheim - Meigs. The aim of this study is to present the technique of this operation, as well as its effectiveness in the treatment of cervical cancer. Results. The distribution of the patients having invasive cervical cancer according to the International Federation of Gynecology and Obstetrics classification was as follows: I B1 - 35.67%, I B2 - 23.17%, II A - 15.48%, II B - 25.68% on average is 21.3 removed lymph glands. The rate of intraoperative and postoperative complications was 8 (4.51%) and 17 (9.60%), respectively. Of the 26 patients who were operated in the period from 2005 - 2010, 13 had stage II B according to the International Federation of Gynecology and Obstetrics; there were 6 lethal outcomes (23.08) and the five-year survival rate was 76.92%. Discussion and conclusion. By applying the proper surgical technique and early prevention of immediate complications, we achieved satisfactory results in operative morbity and mortality, intraoperative and postoperative complications of the lesion for radical surgery by the Wertheim- Meigs-in the treatment of cancer of the uterus in the I B - II B stage according to the International Federation of Gynecology and Obstetrics classification.

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Noninvasive CT radiomic model for preoperative prediction of lymph node metastasis in early cervical carcinoma

British Journal of Radiology ◽

10.1259/bjr.20190558 ◽

2020 ◽

Vol 93 (1108) ◽

pp. 20190558

Author(s):

Jiaming Chen ◽

Bingxi He ◽

Di Dong ◽

Ping Liu ◽

Hui Duan ◽

...

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Cervical Carcinoma ◽

Ct Images ◽

International Federation ◽

Clinical Feature ◽

Data Set ◽

Node Metastasis ◽

Gynecology And Obstetrics ◽

Model Combining

Objective: To build and validate a CT radiomic model for pre-operatively predicting lymph node metastasis in early cervical carcinoma. Methods and materials: A data set of 150 patients with Stage IB1 to IIA2 cervical carcinoma was retrospectively collected from the Nanfang hospital and separated into a training cohort (n = 104) and test cohort (n = 46). A total of 348 radiomic features were extracted from the delay phase of CT images. Mann–Whitney U test, recursive feature elimination, and backward elimination were used to select key radiomic features. Ridge logistics regression was used to build a radiomic model for prediction of lymph node metastasis (LNM) status by combining radiomic and clinical features. The area under the receiver operating characteristic curve (AUC) and κ test were applied to verify the model. Results: Two radiomic features from delay phase CT images and one clinical feature were associated with LNM status: log-sigma-2–0 mm-3D_glcm_Idn (p = 0.01937), wavelet-HL_firstorder_Median (p = 0.03592), and Stage IB (p = 0.03608). Radiomic model was built consisting of the three features, and the AUCs were 0.80 (95% confidence interval: 0.70 ~ 0.90) and 0.75 (95% confidence intervalI: 0.53 ~ 0.93) in training and test cohorts, respectively. The κ coefficient was 0.84, showing excellent consistency. Conclusion: A non-invasive radiomic model, combining two radiomic features and a International Federation of Gynecology and Obstetrics stage, was built for prediction of LNM status in early cervical carcinoma. This model could serve as a pre-operative tool. Advances in knowledge: A noninvasive CT radiomic model, combining two radiomic features and the International Federation of Gynecology and Obstetrics stage, was built for prediction of LNM status in early cervical carcinoma.

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Robot-Assisted Radical Hysterectomy in Cervical Carcinoma: The Belgian Experience

International Journal of Gynecological Cancer ◽

10.1097/igc.0000000000000536 ◽

2015 ◽

Vol 25 (9) ◽

pp. 1690-1696 ◽

Cited By ~ 9

Author(s):

An Segaert ◽

Koen Traen ◽

Philippe Van Trappen ◽

Frederik Peeters ◽

Karin Leunen ◽

...

Keyword(s):

Cervical Cancer ◽

Radical Hysterectomy ◽

Oncological Outcome ◽

International Federation ◽

Adjuvant Radiation ◽

Robot Assisted ◽

Gynecology And Obstetrics ◽

Stage Ia ◽

Disease Free

ObjectiveThe purpose of this study was to report the experience and oncological outcome of robot-assisted radical hysterectomies (RRHs) for cervical cancer performed in Belgium.MethodsPatients undergoing RRH for cervical cancer (n = 109) were prospectively collected between July 2007 and April 2014 in the 5 Belgian centers performing RRH for cervical cancer.ResultsThe median age of the patients was 46 years (range, 31–80 years). Histological types included squamous cell carcinoma in 61 patients, adenocarcinoma in 22 patients, adenosquamous in 8 patients, endometrioid carcinoma in 2 patients, and other types (n = 16). The International Federation of Gynecology and Obstetrics stage distribution was IA (n = 9), stage IB1 (n = 71), stage IB2 (n = 4), stage II (n = 24), and unknown (n = 1). Twenty-four patients received adjuvant therapy, 17 patients underwent radiochemotherapy, and 7 underwent adjuvant radiation. Eighteen patients relapsed, and 5 died of disease. The median follow-up was 27.5 months (range, 3–82 months). The 2- and 5-year overall survivals were 96% and 89%, respectively. The 2- and 5-year disease-free survivals (DFSs) were 88% and 72%, respectively. The 2-year DFS per stage was 100% for IA, 88% for IB1, 100% for IB2, and 83% for II. The 5-year DFS per stage was 100% for stage IA and 75% for IB1. The complications were as expected for radical hysterectomy.ConclusionsThis series confirms the feasibility and safety of RRH not only in cervical cancer stage IA to IB1, but also after neoadjuvant chemotherapy in stage IB2 to IIB.

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Stage IIA1 Versus Stage IIA2 Cervical Cancer: Does the New Staging Criteria Predict Survival?

International Journal of Gynecological Cancer ◽

10.1097/igc.0b013e3182138648 ◽

2011 ◽

Vol 21 (4) ◽

pp. 711-716 ◽

Cited By ~ 10

Author(s):

Gunjal Garg ◽

Jay P. Shah ◽

Eugene P. Toy ◽

Carl Christensen ◽

Gunter Deppe ◽

...

Keyword(s):

Cervical Cancer ◽

Overall Survival ◽

Radical Hysterectomy ◽

Tumor Size ◽

International Federation ◽

Primary Radiation ◽

Adjuvant Radiation ◽

Patient Age ◽

Gynecology And Obstetrics ◽

Patient Âgé

Objective:(1) To determine the correlation of 2008 International Federation of Gynecology and Obstetrics staging system with survival in patients with stage IIA cervical cancer, (2) to elucidate the treatment patterns in stage IIA1 and stage IIA2 cervical cancer, and (3) to investigate whether radical hysterectomy or radiation influenced overall survival.Methods:Data were extracted from the Surveillance, Epidemiology and End Results database between 1988 and 2005. Statistical analysis usedχ2test, Kaplan-Meier method, Cox regression, and logistic regression.Results:Of the 560 women, 271 (48.4%) had stage IIA1, and 289 (51.6%) had stage IIA2 cervical cancer. Stage IIA2 patients were younger than stage IIA1 patients (mean age, 49 years vs 54 years;P= 0.01). Stage IIA1, compared with stage IIA2, differed significantly regarding the administration of primary radiation (47.2% vs 64.7%,P< 0.001) and adjuvant radiation (60.5% vs 77.5%,P= 0.006). The following variables were significantly associated with the performance of radical hysterectomy: patient age, 65 years or younger, tumor size, ≤2 cm or lesser, high tumor grade, and nonsquamous tumor histology. The incidence of adjuvant radiation after radical hysterectomy was high (48% [tumor size, ≤2 cm] to 86% [tumor size, >6 cm]). The 5-year overall survival was not significantly different between stages IIA1 and IIA2 (65.8% vs 59.5%,P= 0.2). Only patient age (P= 0.01), tumor size (P= 0.02), and lymph node status (P= 0.002) were independent predictors of survival. When controlled for other contributing factors, there was no significant difference in survival between patients treated by radical hysterectomy and primary radiation.Conclusions:The 2008 International Federation of Gynecology and Obstetrics staging criteria is not an independent predictor of survival in stage IIA cervical cancer. Given the equivalent efficacy of radical hysterectomy and radiation, attention should be paid to the high risk of adjuvant radiation in these patients.

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Comparison of The International Federation of Gynecology and Obstetrics (FIGO) 2018 and 2009 Staging Systems for Operated Cervical Carcinoma

Turkish Journal of Oncology ◽

10.5505/tjo.2021.2786 ◽

2021 ◽

Author(s):

fatma sert

Keyword(s):

Cervical Carcinoma ◽

International Federation ◽

Gynecology And Obstetrics ◽

Staging Systems

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Platinum-Based Neoadjuvant Chemotherapy Followed by Radical Surgery for Cervical Carcinoma International Federation of Gynecology and Obstetrics Stage IB2-IIB

International Journal of Gynecological Cancer ◽

10.1097/igc.0b013e3182a616d2 ◽

2013 ◽

Vol 23 (9) ◽

pp. 1647-1654 ◽

Cited By ~ 16

Author(s):

Lucas Minig ◽

Nicoletta Colombo ◽

Vanna Zanagnolo ◽

Fabio Landoni ◽

Luca Bocciolone ◽

...

Keyword(s):

Prognostic Factors ◽

Neoadjuvant Chemotherapy ◽

Cervical Carcinoma ◽

Progression Free Survival ◽

Figo Stage ◽

International Federation ◽

Gynecology And Obstetrics ◽

European Institute ◽

Parametrial Involvement ◽

Node Metastases

ObjectiveThe objective of this study was to determine the response rate to chemotherapy, as well as the progression-free survival (PFS), the overall survival (OS), and the main prognostic factors in patients treated at the European Institute of Oncology in Milan, Italy.MethodsRetrospective data were collected on patients with uterine cervical carcinoma, International Federation of Gynecology and Obstetrics (FIGO) stage IB2 to IIB, who underwent platinum-based neoadjuvant chemotherapy (NACT) followed by radical hysterectomy.ResultsA total of 121 patients were studied. The median (range) age was 45 years old (23–69 years). The distribution of patients by International Federation of Gynecology and Obstetrics stage was as follows: n = 88 (73%) with stage IB2, n = 7 (6%) with stage IIA, and n = 26 (21%) with stage IIB. The median (range) tumor size was 50 mm (20–90 mm). Neoadjuvant chemotherapy involved a combination of cisplatin, paclitaxel, and ifosfamide in 80 patients (65%). Using this treatment, 112 patients (93%) received 3 cycles of NACT, whereas 6 (5%) received 4 cycles. Complete and partial pathology response was observed in 9 patients (7%) and 79 patients (66%), respectively. Adjuvant radiotherapy was not necessary in 65% of patients. A 5-year PFS and OS of 58% and 71%, respectively, were observed. Independent prognostic factors for PFS and OS were identified, including response to NACT, persistent lymph node metastases, and parametrial involvement.ConclusionsNeoadjuvant chemotherapy in this group of tumors is a promising treatment strategy and should be discussed with patients. Although these results are comparable to those obtained by standard chemoradiation treatment, one strategy should not be recommended over the other until the results of the ongoing phase 3 trial for NACT are released.

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Lacunae in International Federation of Gynecology and Obstetrics (FIGO) Classification for Cervical Carcinoma

International Journal of Gynecological Cancer ◽

10.1097/igc.0b013e31829783c4 ◽

2013 ◽

Vol 23 (6) ◽

pp. 1071-1077 ◽

Cited By ~ 5

Author(s):

Jignesh Meva ◽

Rahul K. Chaudhary ◽

Debanshu Bhaduri ◽

Manish Bhatia ◽

Sharanabasappa Hatti ◽

...

Keyword(s):

Cervical Carcinoma ◽

International Federation ◽

Gynecology And Obstetrics ◽

Figo Classification

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Robotic Versus Laparoscopic Radical Hysterectomy in Cervical Cancer Patients: A Matched-Case Comparative Study

International Journal of Gynecological Cancer ◽

10.1097/igc.0000000000000232 ◽

2014 ◽

Vol 24 (8) ◽

pp. 1466-1473 ◽

Cited By ~ 25

Author(s):

Tae-Hyun Kim ◽

Chel Hun Choi ◽

June-Kuk Choi ◽

Aera Yoon ◽

Yoo-Young Lee ◽

...

Keyword(s):

Cervical Cancer ◽

Radical Hysterectomy ◽

Surgical Outcomes ◽

Invasive Cervical Cancer ◽

Operating Time ◽

International Federation ◽

Complication Rates ◽

Laparoscopic Radical Hysterectomy ◽

Gynecology And Obstetrics ◽

Estimated Blood Loss

ObjectiveThis study aimed to compare initial surgical outcomes and complication rates of patients with early-stage cervical cancer who underwent robotic radical hysterectomy (RRH) and conventional laparoscopic radical hysterectomy (LRH).MethodsPatients diagnosed with invasive cervical cancer (International Federation of Gynecology and Obstetrics stage I-IIA) who underwent RRH (n = 23) at Samsung Medical Center from January 2008 to May 2013 were compared with matched patients who underwent LRH (n = 69) during the same period. The 2 surgical groups were matched 3:1 for variables of age, body mass index, International Federation of Gynecology and Obstetrics stage, histological subtype, tumor size, and node positivity. All patient information and surgical and postoperative follow-up data were retrospectively collected.ResultsOperating time was significantly longer (317 vs 236 minutes; P < 0.001) in the RRH group compared with the LRH group but mean estimated blood loss was significantly reduced in the RRH group (200 vs 350 mL; P = 0.036). Intraoperative and postoperative complications were not significantly different between the 2 groups (4.3% for RRH vs 1.45% for LRH; P = 0.439). Recurrences were 2 (8.7%) in the RRH and 7 (10.1%) in the LRH group. The overall 3-year recurrence-free survival was 91.3% in RRH group and 89.9% in the LRH group (P = 0.778).ConclusionsAlthough operating time was longer in the RRH cases because of lesser experience on robotic platform, we showed that surgical outcomes and complication rate of RRH were comparable to those of LRH. In addition, surgical skills for LRH easily and safely translated to RRH in case of experienced laparoscopic surgeon.

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